منابع مشابه
974 Platelet Membrane Glycoproteins
Glycoproteins I Ib / I I Ia form a Ca2+-dependent complex that functions as the fibrinogen receptor on human platelets (1). Several reports have indicated that this fibrinogen receptor is also expressed on the surface of human monocytes (2-4). Of three monoclonal antibodies directed against platelet I Ib/ I I Ia , two were reported to give a positive reaction with monocytes as well (4). Other i...
متن کاملGlycoproteins of the lysosomal membrane
Three glycoprotein antigens (120, 100, and 80 kD) were detected by mono- and/or polyclonal antibodies generated by immunization with highly purified rat liver lysosomal membranes. All of the antigens were judged to be integral membrane proteins based on the binding of Triton X-114. By immunofluorescence on normal rat kidney cells, a mouse monoclonal antibody to the 120-kD antigen co-stained wit...
متن کاملPlatelet membrane glycoproteins: historical perspectives
The function of blood platelets to prevent blood loss at injured sites in the vasculature depends largely on their capacity to adhere, aggregate, promote coagulation and secrete factors that induce vasoconstriction and recruit inflammatory cells. Produced in large numbers from megakaryocytes, platelets enter the circulation for 7–10 days primed to fulfill their hemostatic function. By 1970, tho...
متن کاملBiogenesis of plasma membrane glycoproteins. Purification and properties of two rat liver plasma membrane glycoproteins.
As a preliminary to a study of the biogenesis of individual plasma membrane glycoproteins, the marker enzyme nucleotide pyrophosphatase (NPPase) and a major rat liver plasma membrane sialoprotein, subsequently found to be identical with the enzyme dipeptidyl peptidase IV (DPP IV), were purified 10,000- and 2,000-fold, respectively, from rat liver. Both were amphipathic proteins which formed def...
متن کاملIdentification of two lysosomal membrane glycoproteins
Two murine lysosome-associated membrane proteins, LAMP-1 of 105,000-115,000 D and LAMP-2 of 100,000-110,000 D, have been identified by monoclonal antibodies that bind specifically to lysosomal membranes. Both glycoproteins were distinguished as integral membrane components solubilized by detergent solutions but not by various chaotropic agents. The lysosome localization was demonstrated by indi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43329-2